【摘要】 人类β-防御素（hBDs）存在于多种器官组织的黏膜上皮细胞内，不仅具有广谱抗细菌、真菌、包膜病毒的活性，还能调节免疫应答和炎症反应，已成为近年来研究的热点。眼球作为一个暴露于体表的器官，易受到各种病原微生物的侵害，造成感染，进而影响视功能。在过去的十余年时间里，许多研究已经证明眼球及其器也像人体内的其他组织一样能够表达和分泌β-防御素，其在眼部的防御保护机制中发挥着重要作用。现就β-防御素的生物学活性、在眼部的表达、与一些眼表疾病的关系及其在眼科的应用前景作一综述。
【关键词】 抗微生物肽； β防御素； 眼科学
DOI：10.3760/cma.j.issn.1674-845X.2014.04.015
作者单位：430060 （但婧、杨燕宁）；445000 恩施自治州恩施临床学院（但婧、宋秀胜）；445700 恩施州龙凤医疗服务中心（宋秀胜）
通信作者：宋秀胜，Email：aeep993@126.com
Distribution of human beta defensins in ocular and its expression in ocular surface disease
Dan Jing*， Yang Yanning， Song Xiusheng. * Renmin Hospital of Wuhan University， Wuhan 430060
Corresponding author：Song Xiu-sheng，Email：aeep993@126.com
【Abstract】 Human beta defensins are widely expressed in the mucosal epithelial cells of organs and tissues. Beta defensins not only exhibit broad-spectrum antimicrobial activity against bacteria， fungi and enveloped virus， but also regulate immune response and inflammation. This research area has become a hot topic in recent years. The eyeball， as an exposed organ， is susceptible to all kinds of pathogens， resulting in infections and visual impairment. Over the past decade， several studies have demonstrated that， like many tissues in the body， the eye and its associated structures secrete and express beta defensins， which play an important role in the defense mechanism of the eye. In this review， we focus on the biological activities of beta defensins， their expression and distribution in the eye， their roles and potential applications in eye diseases.
【Key words】 Anti-microbial peptide； Beta-Defensin； Ophthalmology